Both of these substances act on the hypothalamus and stimulate it to GnRH secretion (Gonadotropin Releasing Hormone). It is along the hypothalamic-pituitary disorders right to the pituitary gland and stimulates it to an increased release of LH (luteinizing
hormone). LH acts on Leydig cells start producing testosterone. In this three-step mechanism means that, for example following a course could be used other than Clomid calmly and tamoxifen, in fact, it is even more appropriate tamoxifen much!

In a study in which various dosages Tamoxifen and Clomid. They found that after 10-day administration of 20 mg of tamoxifen daily, will increase the levels of LH comparable to the level that was measured with the use of Clomid 150 mg a day! According to this study can be considered as tamoxifen for a better candidate for re-established endogenous testosterone production as Clomid (you can only realize the price difference when describing the dose and also lower toxicity of small doses of the liver).

Price and toxicity are not the only reasons to give preference to tamoxifen. Clomid is in fact one is not very suitable property: at high doses and prolonged use reduces the sensitivity of pituitary cells to GnRH and thus reduces its effectiveness. When tamoxifen was observed the opposite effect. This has also been observed in experiments on pituitary cell cultures and is also responsible clinical observations in patients on chronic antiestrogens. This is probably responsible for this fact that Clomid is preserved in a small percentage of internal activities for estorgénové receptors, the inner activity of tamoxifen for these receptors is virtually zero (intrinsic activity is the ability of a substance to activate the receptor to which it has an affinity).

Based on the foregoing that, while Clomid no question functions as an anti-estrogen, and helps to restore the production of testosterone, tamoxifen appears to be the better choice.